ING4 anticorps (C-Term)

N° du produit ABIN1944775

Détail du produit anti-ING4 anticorps

Antigène: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Épitope: AA 162-195, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ING4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, C, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.

Clone: RB47839

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ING4 (ABIN1944775)

Raho, Miranda, Tamborini, Pierotti, Greco: "Detection of novel mRNA splice variants of human ING4 tumor suppressor gene." dans: Oncogene, Vol. 26, Issue 36, pp. 5247-57, (2007) (PubMed).

Shiseki, Nagashima, Pedeux, Kitahama-Shiseki, Miura, Okamura, Onogi, Higashimoto, Appella, Yokota, Harris: "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity." dans: Cancer research, Vol. 63, Issue 10, pp. 2373-8, (2003) (PubMed).

Détails sur ING4

Antigène: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Autre désignation: ING4 (ING4 Produits)

Synonymes: anticorps wu:fb11d09, anticorps wu:fb50e02, anticorps zgc:110619, anticorps ING4, anticorps my036, anticorps p29ING4, anticorps D6Wsu147e, anticorps D6Xrf92, anticorps inhibitor of growth family, member 4, anticorps inhibitor of growth family member 4, anticorps ing4, anticorps ING4, anticorps Ing4

Sujet: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).

Poids moléculaire: 28530

ID gène: 51147

UniProt: Q9UNL4