SP1 anticorps (Sp1 Transcription Factor)

Details for Product anti-SP1 Antibody No. ABIN1944791
Antigène
  • fc18h09
  • zgc:85950
  • wu:fc18h09
  • SP1
  • 1110003E12Rik
  • AA450830
  • AI845540
  • Sp1-1
  • sp1 transcription factor
  • Sp1 transcription factor
  • Sp1 transcription factor L homeolog
  • trans-acting transcription factor 1
  • sp1
  • SP1
  • Sp1
  • sp1.L
Reactivité
Humain
245
138
131
22
14
14
11
11
10
9
6
3
3
3
2
Hôte
Souris
204
28
23
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp SP1 est non-conjugé
9
5
5
5
5
5
5
5
4
3
3
3
2
1
1
1
1
1
Application
Western Blotting (WB)
205
111
79
77
33
28
23
13
8
8
3
3
3
3
1
Options
Immunogène This SP1 antibody is generated from a mouse immunized with a recombination protein from the human SP1.
Clone 1326CT463-109-176
Isotype IgG1
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Plasmids, Primers & others Plasmids, Primers & others SP1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation SP1 (SP1 Antibody Extrait)
Sujet Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.
Synonyms: Transcription factor Sp1, SP1, TSFP1
Poids moléculaire 80693 Da
ID gène 6667
UniProt P08047
Pathways Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction
Indications d'application WB - 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Images (Fournisseur)
Western Blotting (WB) image for anti-Sp1 Transcription Factor (SP1) antibody (ABIN1944791) anti-Sp1 Transcription Factor (SP1) antibody
Produit citée dans: Takahara, Kanazu, Yanagisawa, Akanuma: "Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing." dans: The Journal of biological chemistry, Vol. 275, Issue 48, pp. 38067-72, 2000 (PubMed).

Kadonaga, Carner, Masiarz, Tjian: "Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain." dans: Cell, Vol. 51, Issue 6, pp. 1079-90, 1988 (PubMed).

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