Paxillin anticorps (Tyr118)

N° du produit ABIN197278

Cet anticorps Lapin Polyclonal détecte spécifiquement Paxillin dans WB et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Paxillin anticorps (Tyr118) (ABIN197278)

Antigène: Paxillin (PXN)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Paxillin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Paxillin anticorps

Épitope: Tyr118

Séquence: H-V-YP-S-F

Specificité: This antibody detects endogenous levels of total Paxillin protein.

Purification: Affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized non-phosphopeptide derived from human Paxillin around the phosphorylation site of tyrosine 118

Information d'application

Indications d'application: WB: 1: 500-1: 1000. IHC: 1: 50-1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur Paxillin

Antigène: Paxillin (PXN)

Autre désignation: Paxillin / PXN

Sujet: Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).Synonyms: FLJ16691

ID gène: 5829

NCBI Accession: NP_001074324

UniProt: P49023

Pathways: Signalisation MAPK, EGFR Signaling Pathway, Response to Growth Hormone Stimulus, Cell-Cell Junction Organization, Maintenance of Protein Location, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling