CCL2 anticorps

N° du produit ABIN2191875

Cet anticorps anti-CCL2 est un anticorps Souris Monoclonal détectant CCL2 dans WB, IHC (p), FACS, Func et IHC (fro). Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour CCL2 anticorps (ABIN2191875)

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCL2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: MNA-1

Détail du produit anti-CCL2 anticorps

Réactivité croisée (Details): Cross reactivity: Human MCP-2 : No, Human MCP-3 : No, Porcine MCP-1 : Yes

Stérilité: 0.2 μm filtered

Isotype: IgG1

Information d'application

Indications d'application: For immunohistochemistry, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies dilutions have to be optimized in user's experimental setting.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Références pour anticorps anti-CCL2 (ABIN2191875)

Wysocki, Zheng, Smith, Lamawansa, Iacopetta, Robertson, Papadimitriou, House, Norman: "Monocyte chemoattractant protein-1 gene expression in injured pig artery coincides with early appearance of infiltrating monocyte/macrophages." dans: Journal of cellular biochemistry, Vol. 62, Issue 3, pp. 303-13, (1997) (PubMed).

Peri, Milanese, Matteucci, Ruco, Zhou, Sozzani, Coletta, Mantovani: "A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells." dans: Journal of immunological methods, Vol. 174, Issue 1-2, pp. 249-57, (1994) (PubMed).

Détails sur CCL2

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Autre désignation: Monocyte Chemotactic Protein-1

Sujet: Monoclonal antibody MNA.1 (formerly known as 5D3-F7) recognizes human natural and recombinant monocyte chemotactic protein-1 (MCP-1). Monocyte chemotactic protein-1 (MCP-1) is a 11 kDa protein belonging to the CC subgroup of the chemokine superfamily, which stimulate the migration of monocytic cells. In contrast, the CXC chemokines predominantly activate polymorphonuclear leukocytes. The coordinated synthesis and release of MCP-1 plays a central role in both acute and chronic inflammatory processes by controlling the influx of phagocytic cells. Furthermore, their state of activation is in concert with primary inflammatory cytokines, such as IL-1, TNF-a, and IL-6. A selective accumulation of MCP-1 in the cerebrospinal fluid (CSF) of AIDS patients with cytomegalovirus encephalitis, but not with other opportunistic infections or primary lymphomas of the central nervous system , has been described. Furthermore, the chemotactic activity of MCP-1 on monocytic cells has been suggested to play a role in psoriasis, rheumatoid arthritis and atherosclerosis. No cross- reactivity of mAb MNA.1 with other cytokines has been detected. Aliases C-C motif chemokine 2, CCL2, small-inducible cytokine A2, MCAF, HC11 Immunogen Recombinant human MCP-1

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylation & l'infection par le SRAS-CoV-2