ASAP3 anticorps

N° du produit ABIN233800

Détail du produit anti-ASAP3 anticorps

Antigène: ASAP3 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASAP3 est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: This antibody was prepared from whole rabbit serum produced by repeated immunizations with recombinant human UPLC1/ASAP3 protein.
Immunogentype:Recombinant

Isotype: IgG

Information d'application

Indications d'application: This protein A purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 100 kDa in size corresponding to UPLC1/ASAP3 protein by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ASAP3 (ABIN233800)

Luo, Kong, Wang, Chen, Liu, Wang, Xu, Wang, Yang: "Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration." dans: Molecular medicine reports, Vol. 9, Issue 2, pp. 387-94, (2014) (PubMed).

Détails sur ASAP3

Antigène: ASAP3 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3))

Autre désignation: Uplc1/Asap3 (ASAP3 Produits)

Synonymes: anticorps DDEFL1, anticorps ddefl1, anticorps zgc:113885, anticorps ACAP4, anticorps CENTB6, anticorps UPLC1, anticorps 9430088F20Rik, anticorps Ddefl1, anticorps Gm140, anticorps ArfGAP with SH3 domain, ankyrin repeat and PH domain 3, anticorps development and differentiation enhancing factor-like 1, anticorps ASAP3, anticorps asap3, anticorps DDEFL1, anticorps Asap3

Sujet: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Anti-UPLC1 (up-regulated in liver cancer 1) / ASAP3 Antibody, also named DDEFL1 (development and differentiation-enhancing factor-like 1) or ASAP3, is a member of the AZAP family of proteins. These proteins catalyze the hydrolysis of GTP bound to ADP-ribosylation factor (Arf) proteins, thereby causing Arf inactivation. For this reason, the ASAPs are generally called ArfGAPs.  The activity of ArfGAPs is dependent on the presence of phosphoinositides and is implicated in cellular processes such as membrane trafficking and remodeling of the actin cytoskeleton.  ASAP3 has been found to be up-regulated in 80% of the hepatocellular carcinomas examined.  Initial biochemical characterization reveals that ASAP3 shows class-specific GAP activity on Arf proteins, preferring Arf5 over Arf1 and Arf6. ASAP3 antibody has beed developed through the NCI antibody collaboration program and is ideal for Cancer and Signal Transduction research.
Synonyms: ASAP3 Antibody, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3, FLJ20199 antibody, Gm140 antibody

ID gène: 55616, 19071867

UniProt: Q8TDY4