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ASAP3 anticorps

ASAP3 Reactivité: Humain ELISA, WB Hôte: Lapin Polyclonal unconjugated
Pubmed (1 reference)
N° du produit ABIN233800
$614.60
Plus frais de port $45.00 et $20.00 pour carboglace
100 μg
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes ASAP3 Anticorps
    ASAP3 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3))
    Reactivité
    • 31
    • 16
    • 16
    • 10
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 45
    • 1
    Lapin
    Clonalité
    • 46
    Polyclonal
    Conjugué
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ASAP3 est non-conjugé
    Application
    • 28
    • 20
    • 18
    • 13
    • 13
    • 7
    • 3
    • 1
    ELISA, Western Blotting (WB)
    Immunogène
    This antibody was prepared from whole rabbit serum produced by repeated immunizations with recombinant human UPLC1/ASAP3 protein.
    Immunogentype:Recombinant
    Isotype
    IgG
  • Indications d'application
    This protein A purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 100 kDa in size corresponding to UPLC1/ASAP3 protein by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Luo, Kong, Wang, Chen, Liu, Wang, Xu, Wang, Yang: "Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration." dans: Molecular medicine reports, Vol. 9, Issue 2, pp. 387-94, (2014) (PubMed).

  • Antigène
    ASAP3 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3))
    Autre désignation
    Uplc1/Asap3 (ASAP3 Produits)
    Synonymes
    DDEFL1, ddefl1, zgc:113885, ACAP4, CENTB6, UPLC1, 9430088F20Rik, Ddefl1, Gm140, ArfGAP with SH3 domain, ankyrin repeat and PH domain 3, development and differentiation enhancing factor-like 1, ASAP3, asap3, DDEFL1, Asap3
    Sujet
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Anti-UPLC1 (up-regulated in liver cancer 1) / ASAP3 Antibody, also named DDEFL1 (development and differentiation-enhancing factor-like 1) or ASAP3, is a member of the AZAP family of proteins. These proteins catalyze the hydrolysis of GTP bound to ADP-ribosylation factor (Arf) proteins, thereby causing Arf inactivation. For this reason, the ASAPs are generally called ArfGAPs.  The activity of ArfGAPs is dependent on the presence of phosphoinositides and is implicated in cellular processes such as membrane trafficking and remodeling of the actin cytoskeleton.  ASAP3 has been found to be up-regulated in 80% of the hepatocellular carcinomas examined.  Initial biochemical characterization reveals that ASAP3 shows class-specific GAP activity on Arf proteins, preferring Arf5 over Arf1 and Arf6. ASAP3 antibody has beed developed through the NCI antibody collaboration program and is ideal for Cancer and Signal Transduction research.
    Synonyms: ASAP3 Antibody, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3, FLJ20199 antibody, Gm140 antibody
    ID gène
    55616, 19071867
    UniProt
    Q8TDY4
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