SOS1 anticorps

N° du produit ABIN238504

Cet anticorps Souris Monoclonal détecte spécifiquement SOS1 dans WB, IF et EIA. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour SOS1 anticorps (ABIN238504)

Antigène: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOS1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Clone: SOS-1

Détail du produit anti-SOS1 anticorps

Specificité: The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein.

Attributs du produit: Synonyms: SOS-1, Son of sevenless homolog 1

Purification: Protein A affinity chromatography.

Immunogène: Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.

Isotype: IgG1

Information d'application

Indications d'application: Western Blotting under reducing conditions (1 μg/mL): Positive control: HeLa human cervix carcinoma cell line. Immunocytochemistry. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 with 15 mM sodium azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch.

Date de péremption: 12 months

Détails sur SOS1

Antigène: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Autre désignation: SOS1

Sujet: The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.Synonyms: SOS-1, Son of sevenless homolog 1

ID gène: 6654

UniProt: Q07889

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling