Presenilin 1 anticorps (AA 313-334)

N° du produit ABIN2443730

L’anticorps anti-Presenilin 1 Monoclonal Souris est utilisé pour la détection de Presenilin 1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour Presenilin 1 anticorps (AA 313-334) (ABIN2443730)

Antigène: Presenilin 1 (PSEN1)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Presenilin 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: APS18

Détail du produit anti-Presenilin 1 anticorps

Épitope: AA 313-334

Fonction: Presenilin 1 (N term) Mouse Monoclonal Antibody (APS18)

Specificité: The antibody recognizes the N-terminal region of the Presenilin 1 with no cross-reactivity observed with Presenilin 2

Immunogène: aa 313-334

Isotype: IgG1

Information d'application

Indications d'application: ELISA 1:1000,WB 1:100,IF 1:1300,IHC 1:1300

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: If reconstituted with deionized water in 250μL: ELISA 1:1000, WB 1:100, IF 1:1300, IHC 1:1300. Optimal dilution has to be determined by the user.

Buffer: Lyophilized protein free tissue culture supernatant

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Date de péremption: 24 months

Détails sur Presenilin 1

Antigène: Presenilin 1 (PSEN1)

Autre désignation: Presenilin 1

Sujet:

PS-1, Protein S182, PSEN1

Presenilin is an integral membrane protein ubiquitously expressed in the brain, it is mainly expressed in neurons where it is localized in the endoplasmic reticulum. Mutations in the presenilin proteins (PSEN1, PSEN2) are linked to an inherited form of Alzheimer's disease in some patients by increasing the production of the longer form of amyloid-beta. Presenilins are thought to affect gamma-secretase by regulating amyloid precursor protein (APP) processing and cleavage of the Notch receptor.

UniProt: P49768

Pathways: Signalisation Notch, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport