SUMO1 anticorps (full length)

N° du produit ABIN2452138

Cet anticorps Rat Monoclonal détecte spécifiquement SUMO1 dans WB, IF, ELISA et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 4+ publications.

Aperçu rapide pour SUMO1 anticorps (full length) (ABIN2452138)

Antigène: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp SUMO1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4D12

Détail du produit anti-SUMO1 anticorps

Épitope: full length

Specificité: Specific to human, simian, mouse and rat SUMO1.

Réactivité croisée (Details): Not tested for other species

Purification: The antibody was produced in serum-free medium and purified by proprietary chromatography procedures under mild conditions.

Stérilité: Sterile filtered

Immunogène: Recombinant GST-fused human SUMO1 (full length)

Isotype: IgG2a kappa

Information d'application

Indications d'application: 1. Western blotting: 1/1,000
2. Immunofluorescence staining: 1/100 dilution
3. Immunohistochemistry,Frozen section: 1/100 dilution
4. ELISA (assay dependent)
Other applications have not been tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS (x1), 50 % glycerol. Azide and carrier free.

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Upon arrival centrifuge briefly and store at -20 C.

Références pour anticorps anti-SUMO1 (ABIN2452138)

Ulrich: "The fast-growing business of SUMO chains." dans: Molecular cell, Vol. 32, Issue 3, pp. 301-5, (2008) (PubMed).

Saitoh, Uchimura, Tachibana, Sugahara, Saitoh, Nakao: "In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies." dans: Experimental cell research, Vol. 312, Issue 8, pp. 1418-30, (2006) (PubMed).

Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." dans: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

Cheng, Bawa, Lee, Gong, Yeh: "Role of desumoylation in the development of prostate cancer." dans: Neoplasia (New York, N.Y.), Vol. 8, Issue 8, pp. 667-76, (2006) (PubMed).

Détails sur SUMO1

Antigène: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Autre désignation: SUMO1

Sujet: SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. There are three confirmed SUMO isoforms in human, SUMO1, SUMO2 and SUMO3. SUMO2 /3 show a high degree of similarity to each other and are distinct from SUMO1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO-1 is conjugated to RanGAP, PML, p53 and IkappaB-alpha to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stability. SUMO1 is encoded as a 101 aa protein and first Met and C-terminal 4 aa are removed from the preprotein.

UniProt: P63165

Pathways: M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway