PILRB anticorps

N° du produit ABIN2459063

Détail du produit anti-PILRB anticorps

Antigène: PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PILRB est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PILRB.

Information d'application

Indications d'application: PILRB antibody can be used for detection of PILRB by ELISA at 1:312500. PILRB antibody can be used for detection of PILRB by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PILRB antibody at -20 °C.

Détails sur PILRB

Antigène: PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))

Autre désignation: PILRB (PILRB Produits)

Synonymes: anticorps FDFACT1, anticorps FDFACT2, anticorps FDFACT, anticorps Fdact, anticorps Pilrb, anticorps paired immunoglobin-like type 2 receptor beta, anticorps paired immunoglobin-like type 2 receptor beta 1, anticorps PILRB, anticorps Pilrb1, anticorps Pilrb

Sujet: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.

Poids moléculaire: 23 kDa

ID gène: 29990

NCBI Accession: NP_038468

UniProt: Q9UKJ0