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IGF1R anticorps (truncated)
IGF1R
Reactivité: Humain
WB, ELISA, IHC
Hôte: Souris
Monoclonal
3C8B1
unconjugated
N° du produit ABIN2464067
Détail du produit anti-IGF1R anticorps
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Antigène
Voir toutes IGF1R Anticorps
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Épitope
Tous les épitopes à travers IGF1R Anticorps.
truncated
Reactivité
Toutes les réactivités sur IGF1R Anticorps
Humain
Hôte
Toutes les hôtes sur IGF1R Anticorps
Souris
Clonalité
Toutes les clonalités sur IGF1R Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers IGF1R Anticorps
Cet anticorp IGF1R est non-conjugé
Application
Tous les applications à travers IGF1R Anticorps.
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Immunogène
Ni-NTA purified truncated recombinant IGF1R-His expressed in E. Coli strain BL21 (DE3).
Clone
3C8B1
Isotype
IgG2b
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Alternatives
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Information d'application
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Indications d'application
Western Blot:1:500 - 1:2,000 IHC(P):1:500 - 1:2,000 IHC(F):1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Stock
-20 °C
Stockage commentaire
IGF1R monoclonal antibody can be stored at -20 °C, stable for one year.
Détails sur IGF1R
(cache)
Antigène
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Autre désignation
IGF1R (IGF1R Produits )
Synonymes
anticorps CMT2N, anticorps CD221, anticorps IGFIR, anticorps IGFR, anticorps JTK13, anticorps IGFIRC, anticorps IGFR1, anticorps IGF-1R, anticorps IGF1R, anticorps DKFZp469I0618, anticorps igf-1r, anticorps xIGF-1R, anticorps xIGFR, anticorps xigf1r, anticorps A330103N21Rik, anticorps D930020L01, anticorps hyft, anticorps igf-ir, anticorps IGF-IR, anticorps IGF-IRb, anticorps wu:fb03h06, anticorps IGF-IRa, anticorps sb:eu1090, anticorps wu:fi20b10, anticorps alanyl-tRNA synthetase, anticorps insulin like growth factor 1 receptor, anticorps insulin-like growth factor 1 receptor, anticorps insulin-like growth factor 1, anticorps insulin-like growth factor I receptor, anticorps insulin like growth factor 1 receptor S homeolog, anticorps insulin-like growth factor 1b receptor, anticorps insulin-like growth factor 1a receptor, anticorps AARS, anticorps IGF1R, anticorps Igf1r, anticorps igf1r, anticorps Igf1, anticorps LOC780503, anticorps LOC100136427, anticorps igf1r.S, anticorps igf1rb, anticorps igf1ra
Sujet
IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
ID gène
3480
UniProt
P08069
Pathways
Signalisation RTK , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process , Autophagy
Vus récemment
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