IGF1R anticorps (N-Term)

N° du produit ABIN391990

Détail du produit anti-IGF1R anticorps

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Épitope: AA 19-51, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IGF1R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This IGF1 Receptor (IGF1R) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-51 amino acids from the N-terminal region of human IGF1 Receptor (IGF1R).

Clone: RB1455-1456

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-IGF1R (ABIN391990)

Sakurai, Shibata, Umezu, Kajiyama, Yamamoto, Ino, Nawa, Kikkawa: "Growth-suppressing function of glypican-3 (GPC3) via insulin like growth factor II (IGF-II) signaling pathway in ovarian clear cell carcinoma cells." dans: Gynecologic oncology, Vol. 119, Issue 2, pp. 332-6, (2010) (PubMed).

Zhang, Hao, Wang, Xiao, Ge, Zhu, Luo, Zhang, Zhang: "Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer." dans: BMC cancer, Vol. 10, pp. 184, (2010) (PubMed).

Détails sur IGF1R

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Autre désignation: IGF1 Receptor (IGF1R) (IGF1R Produits)

Synonymes: anticorps CMT2N, anticorps CD221, anticorps IGFIR, anticorps IGFR, anticorps JTK13, anticorps IGFIRC, anticorps IGFR1, anticorps IGF-1R, anticorps IGF1R, anticorps DKFZp469I0618, anticorps igf-1r, anticorps xIGF-1R, anticorps xIGFR, anticorps xigf1r, anticorps A330103N21Rik, anticorps D930020L01, anticorps hyft, anticorps igf-ir, anticorps IGF-IR, anticorps IGF-IRb, anticorps wu:fb03h06, anticorps IGF-IRa, anticorps sb:eu1090, anticorps wu:fi20b10, anticorps alanyl-tRNA synthetase, anticorps insulin like growth factor 1 receptor, anticorps insulin-like growth factor 1 receptor, anticorps insulin-like growth factor 1, anticorps insulin-like growth factor I receptor, anticorps insulin like growth factor 1 receptor S homeolog, anticorps insulin-like growth factor 1b receptor, anticorps insulin-like growth factor 1a receptor, anticorps AARS, anticorps IGF1R, anticorps Igf1r, anticorps igf1r, anticorps Igf1, anticorps LOC780503, anticorps LOC100136427, anticorps igf1r.S, anticorps igf1rb, anticorps igf1ra

Sujet: The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

Poids moléculaire: 154793

ID gène: 3480

NCBI Accession: NP_000866

UniProt: P08069

Pathways: Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy