APAF1 anticorps (AA 307-388)

N° du produit ABIN2467772

L’anticorps anti-APAF1 Polyclonal Poulet est utilisé pour la détection de APAF1 dans des échantillons de Humain et Souris. Il a été validé pour WB.

Aperçu rapide pour APAF1 anticorps (AA 307-388) (ABIN2467772)

Antigène: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Reactivité: Humain, Souris

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp APAF1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-APAF1 anticorps

Épitope: AA 307-388

Purification: Antigen affinity-purified

Information d'application

Indications d'application: Apaf-1 antibody can be used for the detection of Apaf-1 by Western blot, may also work for IHC and ICC.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Agent conservateur: Without preservative

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: 4 °C/-20 °C

Stockage commentaire: APAF1 antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Détails sur APAF1

Antigène: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Autre désignation: APAF1

Sujet: Apoptotic protease activating factor 1. Apaf-1 is a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Poids moléculaire: 141.8 kDa (calculated)

ID gène: 317

NCBI Accession: NP_863658

UniProt: O14727

Pathways: Signalisation p53, Apoptose, Caspase Cascade in Apoptosis, Tube Formation, Positive Regulation of Endopeptidase Activity