anticorps Kv1.3-glyb, anticorps kv1.3, anticorps Kv1.3B, anticorps kcna3b-a, anticorps HGK5, anticorps HLK3, anticorps HPCN3, anticorps HUKIII, anticorps KV1.3, anticorps MK3, anticorps PCN3, anticorps Kca1-3, anticorps Kv1.3, anticorps Mk-3, anticorps cKv1.1, anticorps potassium voltage-gated channel subfamily A member 3, anticorps potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog, anticorps potassium voltage-gated channel, shaker-related subfamily, member 3, anticorps KCNA3, anticorps kcna3.S, anticorps Kcna3
Sujet
The Kv1.3 potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the Shaker potassium channel subfamily which includes Kv1.1, Kv1.2, Kv1.4 and Kv1.5. Potassium channels are mainly found in plasma membranes but are not generally distributed over the cell surface. Potassium channels catalyze the rapid permeation of potassium ions while rejecting biologically abundant potential competitors such as sodium, calcium and magnesium. Ion selectivity and high through put rate of potassium channels is accomplished by precise co-ordination of dehydrated potassium by the protein and multiple ion occupancy within the permeation pathway. All potassium channels carry out the formation of a transmembrane leak specific for potassium ions. Since cells almost universally maintain cytoplasmic potassium concentrations higher than those extracellularly, the opening of a potassium channel implies a negative ongoing change in electrical voltage across the cell membrane. This may result in termination of the action potential of electrically excitable cells including nerve, muscle and pancreatic beta cells. In non-excitable cells, potassium channels play important roles in the cellular potassium recycling required for electrolyte balance effected by the renal epithelium.Synonyms: HGK5, HLK3, HPCN3, HuKIII, Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit Kv1.3