CACNG4 anticorps

N° du produit ABIN265042

Détail du produit anti-CACNG4 anticorps

Antigène: CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNG4 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to CACNG4.

Purification: Purified

Immunogène: Synthetic peptide derived from the rat calcium channel gamma4 subunit conjugated to KLH

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 5- 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur CACNG4

Antigène: CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))

Autre désignation: CACNG4 (CACNG4 Produits)

Synonymes: anticorps CACNG4, anticorps AI413107, anticorps AW491861, anticorps calcium voltage-gated channel auxiliary subunit gamma 4, anticorps calcium channel, voltage-dependent, gamma subunit 4, anticorps CACNG4, anticorps Cacng4

Sujet: Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits alpha1, alpha2/delta, beta in a 1:1:1 stoichiometry1. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the alpha1 subunits contain the ion channel pore while the auxiliary alpha2/delta and beta subunits confer optimal cell surface expression and channel kinetics. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the alpha1, alpha2/delta, beta core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed gamma 1. Upon co-expression with the alpha1.1, alpha2/delta1, beta1a subunits of the skeletal muscle VDCC, gamma subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel. Together, these results suggest that gamma subunits modulate skeletal muscle VDCCs by stabilising their conformation. The gamma 4 subunit is specifically localized in the brain, with the gamma 2 and gamma 3 subunits. It shares >60 % sequence homology with the gamma 2 and gamma 3 subunits and ~25 % sequence homology with the gamma 1 and gamma 5 subunits.Synonyms: Neuronal voltage-gated calcium channel gamma-4 subunit, Voltage-dependent calcium channel gamma-4 subunit

ID gène: 27092

NCBI Accession: NP_055220

UniProt: Q9UBN1