NOTUM anticorps

N° du produit ABIN265168

Détail du produit anti-NOTUM anticorps

Antigène: NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOTUM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody detects Notum.

Purification: Purified

Immunogène: Recombinant full-length notum protein from Mouse

Isotype: IgG

Information d'application

Indications d'application: Western blot: 5-10 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the product (in aliquots) at -20 °C. Can be shipped at 2-8 °C.

Détails sur NOTUM

Antigène: NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))

Autre désignation: Notum (NOTUM Produits)

Synonymes: anticorps 5730593N15Rik, anticorps RGD1307119, anticorps notum, palmitoleoyl-protein carboxylesterase, anticorps notum pectinacetylesterase homolog (Drosophila), anticorps NOTUM, palmitoleoyl-protein carboxylesterase, anticorps NOTUM, anticorps Notum

Sujet: Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the alpha/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.

ID gène: 77583

NCBI Accession: NP_780472

UniProt: Q8R116