CHEK2 anticorps
Aperçu rapide pour CHEK2 anticorps (ABIN265349)
Antigène
Voir toutes CHEK2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- Chk2 (Q510) antibody detects endogenous levels of Chk2 protein. Species: Human. Others not tested.
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Attributs du produit
- Synonyms: CHEK2, CHEK-2, CHK-2, RAD53, Cds1, Serine/threonine-protein kinase Chk2, CHK2checkpoint homolog
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Purification
- Aff - Purified
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anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reactivité: Humain WB, ELISA, IF, IHC (p) Hôte: Souris Monoclonal 4B7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibodyCHEK2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibodyCHEK2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibodyCHEK2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reactivité: Humain, Singe, Chien WB, IHC, IF, IHC (p), FACS Hôte: Souris Monoclonal 10G7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reactivité: Humain, Chien WB, IHC, IF, IHC (p), IP, FACS Hôte: Souris Monoclonal 5C4 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reactivité: Humain, Chien WB, IHC, IHC (p), IP, FACS Hôte: Souris Monoclonal 2H5 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyKD Validated CHEK2 Reactivité: Humain WB, IF (p), FACS Hôte: Lapin Monoclonal 23GB3460 unconjugated Recombinant Antibody
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Indications d'application
- ELISA: 1: 20000~1: 40000. WB: 1: 500~1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Restrictions
- For Research Use only
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Stock
- 4 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
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Date de péremption
- 12 months
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- CHEK2 (Checkpoint Kinase 2 (CHEK2))
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Autre désignation
- CHK2
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Sujet
- Cell cycle events are regulated by the sequential activation and deactivation of cyclindependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved inthese processes as regulators of Cdks. Chk1 and Chk2 both function as essentialcomponents in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response toDNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A,Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators bydephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown thatChk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylatedform of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation byChk1.
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UniProt
- O96017
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Pathways
- Signalisation p53, Apoptose, Cycle Cellulaire
Antigène
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