Claudin 5 anticorps

N° du produit ABIN265364

Détail du produit anti-Claudin 5 anticorps

Antigène: Claudin 5 (CLDN5)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claudin 5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Claudin 5 protein. (region surrounding Ser201)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1/40000approx. 1/60000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Claudin 5

Antigène: Claudin 5 (CLDN5)

Autre désignation: Claudin-5 / CLDN5 (CLDN5 Produits)

Synonymes: anticorps AWAL, anticorps BEC1, anticorps CPETRL1, anticorps TMVCF, anticorps cld5, anticorps awal, anticorps bec1, anticorps claudin-5, anticorps cpetrl1, anticorps tmvcf, anticorps AI854493, anticorps MBEC1, anticorps Tmvcf, anticorps cldn5, anticorps zgc:85723, anticorps zgc:103419, anticorps claudin 5, anticorps Claudin-5, anticorps claudin 5 (transmembrane protein deleted in velocardiofacial syndrome), anticorps claudin 5a, anticorps claudin 5b, anticorps claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) L homeolog, anticorps CLDN5, anticorps cld5, anticorps cldn5, anticorps Cldn5, anticorps cldn5a, anticorps cldn5b, anticorps cldn5.L

Sujet: The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrone, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.The human claudin-5 gene maps to chromosome 22q11.21.Synonyms: AWAL, Bec1, Brain endothelial cell clone 1 protein, Lung-specific membrane protein, TMDVCF, TMVCF, Transmembrane protein deleted in VCFS

Poids moléculaire: approx. 23 kDa

ID gène: 7122

NCBI Accession: NP_001124333

UniProt: O00501

Pathways: Hepatitis C