KIR2DL3 anticorps (FITC)

N° du produit ABIN2661521

Détail du produit anti-KIR2DL3 anticorps (FITC)

Antigène: KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KIR2DL3 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.

Clone: DX27

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur KIR2DL3

Antigène: KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))

Autre désignation: CD158b (KIR2DL3 Produits)

Synonymes: anticorps CD158B2, anticorps CD158b, anticorps GL183, anticorps KIR-023GB, anticorps KIR-K7b, anticorps KIR-K7c, anticorps KIRCL23, anticorps NKAT, anticorps NKAT2, anticorps NKAT2A, anticorps NKAT2B, anticorps p58, anticorps killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3, anticorps KIR2DL3

Sujet: CD158b is expressed on natural killer cells and a subset of T cells. It is a member of the immunoglobulin superfamily containing two immunoglobulin C2-type domains. Both variants and alternative isoforms of CD158b have been reported. The interaction of CD158b with specific HLA-C antigens on a target cell (HLA-Cw1, HLA-Cw3, HLA-Cw7 alleles, for example) inhibits cytotoxicity and prevents target cell lysis and death. The interactions between KIR and MHC class I are thought to be important in NK cell and T cell regulation following antigen stimulation. The absence of ligands for KIRs may lower the threshold for activation through activating receptors and increase inflammation and susceptibility to autoimmune disease.

Pathways: Cancer Immune Checkpoints