LILRB4 anticorps (PE)

N° du produit ABIN2662685

Détail du produit anti-LILRB4 anticorps (PE)

Antigène: LILRB4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))

Reactivité: Souris

Hôte: Hamster arménien

Clonalité: Monoclonal

Conjugué: Cet anticorp LILRB4 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: H1-1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur LILRB4

Antigène: LILRB4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))

Autre désignation: CD85k (LILRB4 Produits)

Synonymes: anticorps CD85K, anticorps ILT-3, anticorps ILT3, anticorps LIR-5, anticorps LIR5, anticorps Gp49b, anticorps HM18, anticorps gp49, anticorps leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4, anticorps leukocyte immunoglobulin like receptor B4, anticorps leukocyte immunoglobulin-like receptor, subfamily B, member 4A, anticorps LILRB4, anticorps Lilrb4a

Sujet: Gp49, also known as ILT3, gp49b1 or CD85k, is a 49 kD glycoprotein expressed on activated NK cells and myeloid cells. It structurally resembles killer inhibitory receptors (KIR). gp49B is a type I membrane protein belonging to the Ig superfamily and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), while gp49A is a truncated molecule without ITIM. Upon activation following interaction with integrin a vb3, the cytoplasmic tail associates with SHP-1 and SHP-2, which results in downregulation of cell activation and cytokine production.