TICAM2 anticorps

N° du produit ABIN2665412

Cet anticorps anti-TICAM2 Monoclonal Souris (Clone 9G1B30) (ABIN2665412) détecte spécifiquement TICAM2 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TICAM2 anticorps (ABIN2665412)

Antigène: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TICAM2 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 9G1B30

Détail du produit anti-TICAM2 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur TICAM2

Antigène: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Autre désignation: TICAM-2

Sujet: TICAM-2, also known as TRIF-related adaptor molecule (TRAM), is a TIR domain containing protein that was found to act as an adaptor molecule during LPS-induced innate immune response. Upon infection by Gram-negative bacteria, TLR4 specifically recognizes LPS and leads to the dimerization of the cytoplasmic TIR domains. The activated TLR4 subsequently recruits the adaptor protein complex containing both TICAM-1 and TICAM-2, resulting in the activation of IFN response factors and production of pro-inflammatory cytokines. In this signaling cascade, TICAM-2 is essential for bridging the interaction between TLR4 and TICAM-1. TICAM-2 is also involved in the regulation of the IL-18 signaling pathway, acting as a sorting adaptor that recruits MYD88 from the cytosol to the membrane region upon activation of IL-1/IL-18 receptors.

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades