TGFB1 anticorps

N° du produit ABIN2665500

Détail du produit anti-TGFB1 anticorps

Antigène: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Reactivité: Mammifères

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TGFB1 est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by antigen-affinity chromatography.

Clone: 21C11

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur TGFB1

Antigène: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Autre désignation: TGF-Beta1 (TGFB1 Produits)

Synonymes: anticorps CED, anticorps DPD1, anticorps LAP, anticorps TGFB, anticorps TGFbeta, anticorps TGF-beta, anticorps TGF-BETA-1, anticorps TGF-beta5, anticorps ced, anticorps dpd1, anticorps lap, anticorps tgf-beta, anticorps tgfb, anticorps tgfb5, anticorps tgfbeta, anticorps TGF-beta1, anticorps TGFbeta1, anticorps Tgfb, anticorps Tgfb-1, anticorps ai39657, anticorps tgfb1, anticorps wu:fb13a07, anticorps xx:ai39657, anticorps TGFB1, anticorps csd, anticorps cdb1, anticorps cdg2, anticorps csd1, anticorps csd2, anticorps csd3, anticorps ebmd, anticorps lcd1, anticorps bigh3, anticorps cdgg1, anticorps betaig-h3, anticorps TGFB4, anticorps transforming growth factor beta 1, anticorps transforming growth factor beta-1, anticorps transforming growth factor beta 1 L homeolog, anticorps transforming growth factor, beta 1, anticorps transforming growth factor, beta 1a, anticorps transforming growth factor beta induced L homeolog, anticorps TGFB1, anticorps Tgfb1, anticorps tgfb1.L, anticorps tgfb1a, anticorps tgfbi.L

Sujet: Transforming growth factor beta 1 (TGF-β1) is a member of the transforming growth factor beta superfamily of cytokines. The TGF-β1 precursor contains 390 amino acids with an N-terminal signal peptide of 29 amino acids required for secretion from a cell, a 249 amino acid pro-region (latency associated peptide or LAP), and a 112 amino acid C-terminal region that becomes the active TGF-β1 upon activation. Both LAP and TGF-β1 exist as homodimers in circulation, but the disulfide linked homodimers of LAP and TGF-β1 remain non-covalently associated, forming the small latent TGF-β complex (SLC, 100 kD). The large latent TGF-β complex (LLC, 235-260 kD) contains a third component, the latent TGF-β binding protein (LTBP), which is linked to LAP by a single disulfide bond. LTBP does not confer latency but is for efficient secretion of the complex to extracellular sites. Free active TGF-β1 can be released (activated) by many factors, including enzymes and low or high pH . TGF-β1 is nearly 100 % conserved across mammalian species. It has diverse biological functions in multiple cellular processes such as regulating proliferation and differentiation of various cell types. TGF-β1 is also an important immunoregulatory cytokine, which is involved in the maintenance of self-tolerance, Th17 differentiation, and T-cell homeostasis.

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints