LAT anticorps
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- Antigène Voir toutes LAT Anticorps
- LAT (Linker For Activation of T Cells (LAT))
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp LAT est non-conjugé
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Application
- Flow Cytometry (FACS)
- Réactivité croisée
- Souris
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- 11B-12
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product LAT Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Upon receipt, store between 2°C and 8°C
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- Antigène
- LAT (Linker For Activation of T Cells (LAT))
- Autre désignation
- LAT (LAT Produits)
- Synonymes
- anticorps LAT, anticorps lat, anticorps LAT1, anticorps pp36, anticorps linker for activation of T-cells, anticorps linker for activation of T cells, anticorps LAT, anticorps lat, anticorps Lat
- Sujet
- LAT is a transmembrane molecule that mediates signaling following the engagement of a number of cell surface receptors including TCR during mature T cell activation, pre-TCR during T cell development, Fc RIII on NK cells, and FcεRI on mast cells.LAT is multiply phosphorylated on tyrosines by ZAP-70 and Syk, which leads to downstream effects that include release of intracellular calcium, PKC activation, MAPK activation and cytoskeletal reorganization.Palmitoylation of LAT is required for its localization to lipid rafts and efficient phosphorylation.
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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