Insulin Receptor anticorps

N° du produit ABIN2689096

Cet anticorps anti-Insulin Receptor est un anticorps Souris Monoclonal détectant Insulin Receptor dans FACS. Adapté pour Humain. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour Insulin Receptor anticorps (ABIN2689096)

Antigène: Insulin Receptor (INSR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Insulin Receptor est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 3B6-IR

Détail du produit anti-Insulin Receptor anticorps

Marque: BD Pharmingen™

Attributs du produit: Reacts with insulin receptor (IR), a glycoprotein composed of two extracellular α-subunits (130 kDa) and two transmembrane β-subunits (95 kDa). It is expressed on human hematopoietic and non-hematopoietic cells, but unlike the insulin-like growth factor receptor (IGF-IR), which is ubiquitous, the insulin receptor is restricted to major target tissues of insulin action. Upon binding insulin, the IR subunits form a heterotetramer of two α and two β subunits resulting in autophosphorylation and activation of the tyrosine kinase activity of the receptor. This ligand-receptor interaction is important in regulating cell metabolism and growth. 3B6/IR monoclonal antibody reacts similarly to anti-human IR α, clone 47-9, an α-subunit antibody. Profile of peripheral blood monocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD220 - Purified - Clone 3B6/IR - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-Insulin Receptor (ABIN2689096)

Prigent, Stanley, Siddle: "Identification of epitopes on the human insulin receptor reacting with rabbit polyclonal antisera and mouse monoclonal antibodies." dans: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 9970-7, (1990) (PubMed).

Soos, OBrien, Brindle, Stigter, Okamoto, Whittaker, Siddle: "Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 14, pp. 5217-21, (1989) (PubMed).

Soos, Siddle, Baron, Heward, Luzio, Bellatin, Lennox: "Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor." dans: The Biochemical journal, Vol. 235, Issue 1, pp. 199-208, (1986) (PubMed).

Détails sur Insulin Receptor

Antigène: Insulin Receptor (INSR)

Autre désignation: CD220

Sujet: Synonyms: Insulin Receptor

Pathways: Signalisation NF-kappaB, Signalisation RTK, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity