CD36 anticorps

N° du produit ABIN2689209

Détail du produit anti-CD36 anticorps

Antigène: CD36

Reactivité: Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD36 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Functional Studies (Func)

Marque: BD Pharmingen™

Attributs du produit: The CRF D-2712 antibody reacts with mouse and rat CD36, an 88- kDa glycoprotein member of the class B scavenger receptor family. CD36 is a multifunctional receptor which has a variety of ligands and is expressed on many cell types. Consequently, it is known by several names, including macrophage scavenger receptor, platelet glycoprotein IV, and fatty acid translocase. Cells which express CD36 include platelets, megakaryocytes, monocytes/macrophages, dendritic cells, erythroid precursors, microvascular endothelia, skeletal, cardiac, and smooth muscle cells, adipocytes, and epithelia of retina, breast, and intestine. Therefore, we would not expect to detect CD36 expression by flow cytometry of leukocytes isolated from naive peripheral lymphoid tissues. This multi-ligand receptor functions in the clearance of apoptotic cells and abnormal erythrocytes (in malaria and sickle-cell anemia), the transport of long-chain fatty acids and oxidized low-density lipoproteins, the regulation of angiogenesis by mediating the effects of thrombospondin-1, and the mediation of coronary vasoconstriction. Cross-linking of cell-surface CD36 with plate-bound CRF D-2712 mAb promotes internalization of photoreceptor outer segment fragments by cultured retinal pigment epithelium.

BD Pharmingen™ Purified Mouse Anti-Mouse CD36 - Purified - Clone CRF D-2712 - Isotype Mouse IgA, κ - Reactivity Ms, Rat - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Recombinant mouse CD36

Clone: CRF D

Isotype: IgA kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-CD36 (ABIN2689209)

Bodart, Febbraio, Demers, McNicoll, Pohankova, Perreault, Sejlitz, Escher, Silverstein, Lamontagne, Ong: "CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart." dans: Circulation research, Vol. 90, Issue 8, pp. 844-9, (2002) (PubMed).

Febbraio, Hajjar, Silverstein: "CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism." dans: The Journal of clinical investigation, Vol. 108, Issue 6, pp. 785-91, (2001) (PubMed).

Finnemann, Silverstein: "Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium." dans: The Journal of experimental medicine, Vol. 194, Issue 9, pp. 1289-98, (2001) (PubMed).

Détails sur CD36

Antigène: CD36

Autre désignation: CD36 (CD36 Produits)

Synonymes: anticorps BDPLT10, anticorps CHDS7, anticorps FAT, anticorps GP3B, anticorps GP4, anticorps GPIV, anticorps PASIV, anticorps SCARB3, anticorps Fat, anticorps Scarb3, anticorps GPIIIB, anticorps PAS-4, anticorps zgc:92513, anticorps CD36 molecule, anticorps CD36 molecule (thrombospondin receptor), anticorps CD36, anticorps Cd36, anticorps cd36

Sujet: Synonyms: Scavenger Receptor

Pathways: Signalisation TLR, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteins