mGluR1 alpha anticorps

N° du produit ABIN2689843

Détail du produit anti-mGluR1 alpha anticorps

Antigène: mGluR1 alpha (mGluR1a) (Glutamate Receptor, Metabotropic 1 alpha (mGluR1a))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp mGluR1 alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Marque: BD Pharmingen™

Attributs du produit: Glutamate is a major excitatory neurotransmitter in mammalian brain. Glutamatergic neurotransmission is mediated by a family of glutamate receptors that can be grouped into two classes, ionotropic (GluR) and metabotropic (mGluR) receptors. The metabotropic glutamate receptors consist of at least seven subtypes that can be divided into three groups on the basis of their sequence similarities, intracellular second messengers and agonist selectivities. These groups are: 1) mGluR1 and mGluR5, 2) mGluR2 and mGluR3, and 3) mGluR4, mGluR6 and mGluR7. mGluR1 and mGluR5 are coupled to the inositol phosphate/Ca[2+] signal transduction pathway, whereas the other five receptors are linked to the inhibition of the cAMP cascade. mRNA analysis shows that the seven receptors have different expression patterns in the central nervous system. For example, the highest level of mGluR1 mRNA expression is found in the cerebellar Purkinje cells. mGluR7 mRNA is moderately expressed in these cells, whereas the mRNA of the other five mGluRs is barely detectable. Three splice variants have been described for mGluR1: mGluR1α (145 kDa), mGluR1β (97 kDa), and mGluR1c (97 kDa).

BD Pharmingen™ Purified Mouse Anti-Rat mGluR1α - Purified - Clone G209-2048 - Isotype Mouse IgG1 - Reactivity Rat - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Recombinant Rat mGluR1 Fusion Protein

Clone: G209

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-mGluR1 alpha (ABIN2689843)

Shigemoto, Abe, Nomura, Nakanishi, Hirano: "Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells." dans: Neuron, Vol. 12, Issue 6, pp. 1245-55, (1994) (PubMed).

Masu, Tanabe, Tsuchida, Shigemoto, Nakanishi: "Sequence and expression of a metabotropic glutamate receptor." dans: Nature, Vol. 349, Issue 6312, pp. 760-5, (1991) (PubMed).

Détails sur mGluR1 alpha

Antigène: mGluR1 alpha (mGluR1a) (Glutamate Receptor, Metabotropic 1 alpha (mGluR1a))

Autre désignation: mGluR1alpha (mGluR1a Produits)

Poids moléculaire: 133 kDa