Reacts with an intracellular epitope of the multidrug resistance protein (MRP1). MRP1 is a 190 kDa integral membrane phosphoglycoprotein, member of the ATP-binding cassette transporter proteins, overexpressed in some drug-selected resistant cell lines and has been shown to cause multidrug resistance in transfected cells.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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4 °C
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Store undiluted at 4°C.
Hipfner, Gauldie, Deeley, Cole: "Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies." dans: Cancer research, Vol. 54, Issue 22, pp. 5788-92, (1994) (PubMed).
Cole, Bhardwaj, Gerlach, Mackie, Grant, Almquist, Stewart, Kurz, Duncan, Deeley: "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line." dans: Science (New York, N.Y.), Vol. 258, Issue 5088, pp. 1650-4, (1993) (PubMed).
Antigène
MRP1
(Macrophage Inflammatory Protein Related Protein 1 (MRP1))