Presenilin 1 anticorps

N° du produit ABIN271789

Cet anticorps Lapin Polyclonal détecte spécifiquement Presenilin 1 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Presenilin 1 anticorps (ABIN271789)

Antigène: Presenilin 1 (PSEN1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Presenilin 1 anticorps

Specificité: This antibody detects endogenous levels of Presenilin 1 protein. (region surrounding Ser28)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur Presenilin 1

Antigène: Presenilin 1 (PSEN1)

Autre désignation: Presenilin-1

Sujet: A novel protein, designated Presenilin 1 (also designated S182) and mapping to the AD3 locus of chromosome 14q24.3, has been described. Mutations in the gene encoding Presenilin 1 have been found in families suffering from early-onset Alzheimer's disease. A highly related protein, designated Presenilin 2 (also designated STM2), shares 80 % amino acid sequence identity with Presenilin 1. Presenilin 1 and Presenilin 2 have similar structures and represent novel members of the seven-pass transmembrane receptor superfamily. Point mutations in the gene encoding Presenilin 2 have been found in Volga German families who suffer from an inherited form of early-onset Alzheimer's disease. Whether these proteins function as ligand-gated ion channels or G protein-coupled receptors has yet to be resolved. ALG-3, the mouse homolog of human Presenilin 2, has been cloned from the mouse liver cDNA library.Synonyms: AD3, AF3, Alzheimer Disease 3, FAD, PS-1, PS1, PSEN1, PSNL1, Presenilin 1, S182

Poids moléculaire: 22, 55 kDa

ID gène: 5663

NCBI Accession: NP_000012

UniProt: P49768

Pathways: Signalisation Notch, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport