PIAS3
Reactivité: Humain, Rat, Souris
WB, IHC (p), EIA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps PIAS3, anticorps Pias3l, anticorps ZMIZ5, anticorps protein inhibitor of activated STAT 3, anticorps protein inhibitor of activated STAT, 3, anticorps protein inhibitor of activated STAT 3 L homeolog, anticorps PIAS3, anticorps pias3, anticorps Pias3, anticorps pias3.L
Sujet
The IL-6 type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization, and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.Synonyms: E3 SUMO-protein ligase PIAS3, Protein inhibitor of activated STAT protein 3