MED24 anticorps

N° du produit ABIN272143

Détail du produit anti-MED24 anticorps

Antigène: MED24 (Mediator Complex Subunit 24 (MED24))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MED24 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of TRAP100 protein. (region surrounding Lys834)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur MED24

Antigène: MED24 (Mediator Complex Subunit 24 (MED24))

Autre désignation: MED24 (MED24 Produits)

Synonymes: anticorps CG7999, anticorps Dmel\\CG7999, anticorps Med24, anticorps Trap100, anticorps dTRAP100, anticorps l(3)psg5, anticorps MED24, anticorps THRAP4, anticorps DpseGA20755, anticorps dpse_GLEANR_1506, anticorps GA20755, anticorps dyak_GLEANR_4540, anticorps DyakGE20715, anticorps GE20715, anticorps dmoj_GLEANR_17526, anticorps DmojGI16770, anticorps GI16770, anticorps dper_GLEANR_4776, anticorps DperGL22535, anticorps GL22535, anticorps dsim_GLEANR_14081, anticorps DsimGD14060, anticorps GD14060, anticorps ARC100, anticorps CRSP100, anticorps CRSP4, anticorps DRIP100, anticorps TRAP100, anticorps 911GSE, anticorps AU040102, anticorps AW547152, anticorps D11Ertd307e, anticorps Gse2, anticorps Pparb2, anticorps Pparbp2, anticorps R75526, anticorps Thrap4, anticorps fc05c04, anticorps thrap4, anticorps trap100, anticorps wu:fc05c04, anticorps Mediator complex subunit 24, anticorps mediator complex subunit 24, anticorps mediator of RNA polymerase II transcription subunit 24, anticorps GA20755 gene product from transcript GA20755-RA, anticorps DyakGE20715-PA, anticorps GI16770 gene product from transcript GI16770-RA, anticorps GL22535 gene product from transcript GL22535-RA, anticorps GD14060 gene product from transcript GD14060-RA, anticorps microRNA 6884, anticorps MED24, anticorps LOC100016544, anticorps LOC100398369, anticorps Dpse\Trap100, anticorps DyakTrap100, anticorps Dmoj\Trap100, anticorps Dper\Trap100, anticorps Dsim\Trap100, anticorps Med24, anticorps MIR6884, anticorps med24

Sujet: In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signaling between transcriptional activators and initiation factors. These complexes include the thyroid hormone receptor-associated protein (TRAP) complex, which interacts with thyroid receptors (TR), vitamin D receptors and other steroid receptors to facilitate hormone induced transcriptional activation. The TRAP complex consists of numerous proteins ranging in size from 20 to 240 kDa, including TRAP95, TRAP100, TRAP150, TRAP220 and TRAP230, and they are characterized by the presence of a nuclear receptor recognition motif, which mediates the ligand-dependent binding of TRAP proteins to the nuclear receptors. TRAP220 and TRAP100 are widely expressed and most abundantly detected in skeletal muscle, heart and placenta. TRAP95, TRAP150 and TRAP230 facilitate TR-induced transcription by associating with an additional transcriptional coactivating complex SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes.Synonyms: ARC100, Activator-recruited cofactor 100 kDa component, CRSP complex 4, CRSP4, Cofactor required for Sp1 transcriptional activation subunit 4, DRIP100, KIAA0130, Mediator complex 24, Mediator of RNA polymerase II transcription subunit 24, THRAP4, TRAP100, Thyroid hormone receptor-associated protein 4, Thyroid hormone receptor-associated protein complex 100 kDa component, Vitamin D3 receptor-interacting protein complex component DRIP100

Poids moléculaire: approx. 110 kDa

ID gène: 9862

NCBI Accession: NP_001072986

UniProt: O75448

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity