FXR2 anticorps

N° du produit ABIN272201

Détail du produit anti-FXR2 anticorps

Antigène: FXR2 (Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FXR2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of FXR2 protein. (region surrounding Glu576)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity-Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur FXR2

Antigène: FXR2 (Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2))

Autre désignation: FXR2 (FXR2 Produits)

Synonymes: anticorps id:ibd5046, anticorps zgc:56215, anticorps zgc:77472, anticorps FMR1L2, anticorps FXR2P, anticorps Fxr2h, anticorps FMR1 autosomal homolog 2, anticorps fragile X mental retardation, autosomal homolog 2, anticorps FXR2, anticorps fxr2, anticorps Fxr2

Sujet: Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene, and in the fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing. The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box). FMR1 can also interact with two fragile X syndrome related factors, FXR1 and FXR2, and these proteins form heterodimers through their N-terminal coilcoiled domains. FMR1 localizes to both the nucleus and the cytoplasm, and since it contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleo-cytoplasmic transport of mRNAs.Synonyms: FMR1L2, Fragile X mental retardation syndrome-related protein 2

Poids moléculaire: approx. 65 kDa

ID gène: 9513

NCBI Accession: NP_004851

UniProt: P51116