CCM2 anticorps

N° du produit ABIN2725247

Détail du produit anti-CCM2 anticorps

Antigène: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCM2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Attributs du produit: Homo sapiens cerebral cavernous malformation 2 (CCM2), transcript variant 2

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogène: Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.

Clone: 5H4

Isotype: IgG2b

Information d'application

Indications d'application: WB 1:2000, IF 1:100,

Commentaires:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur CCM2

Antigène: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Autre désignation: CCM2 (CCM2 Produits)

Synonymes: anticorps C7orf22, anticorps OSM, anticorps malcavernin, anticorps CCM2, anticorps BC029157, anticorps TUF2, anticorps vtn, anticorps zgc:110233, anticorps CCM2 scaffolding protein, anticorps cerebral cavernous malformation 2, anticorps malcavernin, anticorps CCM2, anticorps Ccm2, anticorps LOC100304744, anticorps ccm2

Sujet: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 48.7 kDa

ID gène: 83605

NCBI Accession: NM_031443

HGNC: 83605

Pathways: Cell-Cell Junction Organization