MYD88 anticorps

N° du produit ABIN2726635

Il existe 3+ publications pour ce produit. L’anticorps anti-MYD88 Monoclonal Souris est utilisé pour la détection de MYD88 dans des échantillons de Humain. Il a été validé pour WB, IHC, FACS et IF.

Aperçu rapide pour MYD88 anticorps (ABIN2726635)

Antigène: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MYD88 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 2B2

Détail du produit anti-MYD88 anticorps

Attributs du produit: Homo sapiens myeloid differentiation primary response gene (88) (MYD88), transcript variant 2

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogène: Full length human recombinant protein of human MYD88 (NP_002459) produced in HEK293T cell.

Isotype: IgG2a

Information d'application

Indications d'application: WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100

Commentaires:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-MYD88 (ABIN2726635)

Mendez, Banerjee: "Proximal Ligation Assay (PLA) on Lung Tissue and Cultured Macrophages to Demonstrate Protein-protein Interaction." dans: Bio-protocol, Vol. 7, Issue 21, (2017) (PubMed).

Caner, Sen Turk, Baris, Cetin, Tepeli, Hacioglu, Sari, Zencir, Dogu, Bagci, Keskin: "MYD88 Expression and L265P Mutation in Mature B-Cell Non-Hodgkin Lymphomas." dans: Genetic testing and molecular biomarkers, Vol. 19, Issue 7, pp. 372-8, (2015) (PubMed).

Choi, Kim, Lee, Kim: "MYD88 expression and L265P mutation in diffuse large B-cell lymphoma." dans: Human pathology, (2013) (PubMed).

Détails sur MYD88

Antigène: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Autre désignation: MYD88

Sujet: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Poids moléculaire: 33.1 kDa

ID gène: 4615

NCBI Accession: NM_002468

HGNC: 4615

Pathways: Signalisation NF-kappaB, Signalisation TLR, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades