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APAF1 anticorps (N-Term)

APAF1 Reactivité: Souris, Rat WB, ELISA, ICC, IP Hôte: Rat Monoclonal 13F11 unconjugated
N° du produit ABIN2745509
  • Antigène Voir toutes APAF1 Anticorps
    APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))
    Épitope
    • 16
    • 15
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-97, N-Term
    Reactivité
    • 82
    • 49
    • 48
    • 15
    • 1
    Souris, Rat
    Hôte
    • 70
    • 8
    • 5
    • 1
    Rat
    Clonalité
    • 64
    • 20
    Monoclonal
    Conjugué
    • 40
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp APAF1 est non-conjugé
    Application
    • 49
    • 27
    • 26
    • 24
    • 20
    • 15
    • 13
    • 11
    • 11
    • 9
    • 8
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunoprecipitation (IP)
    Specificité
    Recognizes the CARD domain of mouse and rat Apaf-1.
     Réactivité croisée
    Souris, Rat (Rattus)
    Aucune reactivité croisée
    Humain
    Réactivité croisée (Details)
    Does not cross-react with human Apaf-1.
    Pureté
    >95 % (SDS-PAGE)
    niveau d'endotoxine
    <0.1EU/μg purified protein (LAL test, Lonza).
    Immunogène
    Recombinant mouse Apaf-1 (aa 1-97) containing the N-terminal CARD domain.
    Clone
    13F11
    Isotype
    IgG2a
    Top Product
    Discover our top product APAF1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Date de péremption
    12 months
  • Antigène
    APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))
    Autre désignation
    Apaf-1 (APAF1 Produits)
    Synonymes
    anticorps APAF1, anticorps ARK, anticorps Apaf-1, anticorps Apaf1, anticorps CG6829, anticorps D-Apaf-1, anticorps DARK, anticorps Dapaf-1, anticorps Dapaf-1/HAC-1, anticorps Dark, anticorps Dark/Apaf-I, anticorps Dark/Dapaf-1/HAC1, anticorps Dark/Hac-1/dApaf-1, anticorps Dark/Hac-1/dApaf1, anticorps Dmel\\CG6829, anticorps Hac-1, anticorps Hac-1/Dark, anticorps Hac1, anticorps T1, anticorps anon-53Fa, anticorps apaf-1, anticorps apaf1, anticorps arc, anticorps ark, anticorps dAPAF-1, anticorps dApaf-1, anticorps dApaf-1/DARK/HAC-1, anticorps dApaf1, anticorps dArk, anticorps dapaf, anticorps dapaf-1, anticorps dapaf-1L, anticorps dapaf-1S, anticorps dark, anticorps dark/dapaf-1/hac-1, anticorps dark/hac-1/dapaf-1, anticorps hac-1, anticorps hac1, anticorps l(2)SH0173, anticorps APAF-1, anticorps CED4, anticorps 6230400I06Rik, anticorps Apaf1l, anticorps fog, anticorps mKIAA0413, anticorps zgc:136543, anticorps Death-associated APAF1-related killer, anticorps apoptotic peptidase activating factor 1 L homeolog, anticorps apoptotic peptidase activating factor 1, anticorps Dark, anticorps apaf1.L, anticorps apaf1, anticorps APAF1, anticorps Apaf1
    Sujet
    Apaf-1 is a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. It contains (from the N terminal) a caspase recruitment domain (CARD), an ATPase domain (NB-ARC), few short helical domains and then several copies of the WD40 repeat domain. Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome, mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis.
    UniProt
    Q9EPV5
    Pathways
    Signalisation p53, Apoptose, Caspase Cascade in Apoptosis, Tube Formation, Positive Regulation of Endopeptidase Activity
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