CD94 anticorps (FITC)
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- Antigène Voir toutes CD94 (KLRD1) Anticorps
- CD94 (KLRD1) (Killer Cell Lectin-Like Receptor Subfamily D, Member 1 (KLRD1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD94 est conjugé à/à la FITC
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Application
- Flow Cytometry (FACS)
- Specificité
- The mouse monoclonal antibody HP-3D9 recognizes an extracellular epitope of CD94, a 70 kDa type II transmembrane glycoprotein expressed on NK cells, NK-T cells, and subsets of CD8+ T cells and gamma/delta T cells.
- Réactivité croisée (Details)
- Human
- Purification
- Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- Cultured human NK cells
- Clone
- HP-3D9
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product KLRD1 Anticorps primaire
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- Indications d'application
- Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
- Commentaires
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The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
- Restrictions
- For Research Use only
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- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets." dans: Blood, Vol. 115, Issue 2, pp. 274-81, (2010) (PubMed).
: "Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 6, pp. 3766-74, (2008) (PubMed).
: "The role of lesional T cells in recalcitrant psoriasis during infliximab therapy." dans: European journal of dermatology : EJD, Vol. 15, Issue 6, pp. 454-8, (2005) (PubMed).
: "The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA-E through mostly shared but partly distinct sets of HLA-E residues." dans: European journal of immunology, Vol. 34, Issue 1, pp. 81-90, (2004) (PubMed).
: "Disordered expression of inhibitory receptors on the NK1-type natural killer (NK) leukaemic cells from patients with hypersensitivity to mosquito bites." dans: Clinical and experimental immunology, Vol. 120, Issue 3, pp. 413-9, (2000) (PubMed).
: "CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes." dans: Immunity, Vol. 5, Issue 2, pp. 163-72, (1996) (PubMed).
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CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets." dans: Blood, Vol. 115, Issue 2, pp. 274-81, (2010) (PubMed).
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- Antigène
- CD94 (KLRD1) (Killer Cell Lectin-Like Receptor Subfamily D, Member 1 (KLRD1))
- Autre désignation
- CD94 (KLRD1 Produits)
- Synonymes
- anticorps CD94, anticorps CD94-B, anticorps Cd94, anticorps killer cell lectin like receptor D1, anticorps killer cell lectin-like receptor subfamily D, member 1, anticorps killer cell lectin-like receptor, subfamily D, member 1, anticorps KLRD1, anticorps Klrd1
- Sujet
- Killer cell lectin like receptor D1,CD94, also known as KLRD1 (killer cell lectin-like receptor D1), is a transmembrane glycoprotein of the C-type lectin family, which forms disulfide-linked heterodimers with NKG2A, B, C, E, H proteins, constituting functionally distinct receptors of NK cells and related cell types. CD94/NKG2A and CD94/NKG2B heterodimers serve as inhibitory, whereas CD94/NKG2C and CD94/NKG2E as activating receptors. The ligand for CD94/NKG2 complexes has been identified as HLA-E. Extent of CD94 expression on NK cell surface can be used to demonstrate their progress through the differentiation process.,KLR-D1, KLRD1, KCLLRD1
- ID gène
- 3824
- UniProt
- Q13241
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