BTRC anticorps (C-Term)

N° du produit ABIN2775273

L’anticorps anti-BTRC Polyclonal Lapin est utilisé pour la détection de BTRC dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin et Cheval. Il a été validé pour WB.

Aperçu rapide pour BTRC anticorps (C-Term) (ABIN2775273)

Antigène: BTRC (beta-Transducin Repeat Containing (BTRC))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BTRC est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BTRC anticorps

Épitope: C-Term

Fonction: Btrc Antibody - C-terminal region

Séquence: LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against Btrc. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42160-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur BTRC

Antigène: BTRC (beta-Transducin Repeat Containing (BTRC))

Autre désignation: Btrc

Sujet:

Background Information: Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.

Gene Name: Beta-transducin repeat containing protein

Alternative Symbols: Sl, HOS, FWD1, Fbw1, Fbw1a, Slimb, b-TrCP, beta-T, Beta-Tr, beta-TrCP, Beta-Trcp1, SCF b-TRCP, E3RSIkappaB, E3RS-IkappaB

Protein Name: F-box/WD repeat-containing protein 1A

Poids moléculaire: 69kDa

ID gène: 12234

NCBI Accession: NP_001032847

UniProt: Q3ULA2

Pathways: Cycle Cellulaire, Signalisation Hedgehog