KCNN2 anticorps (C-Term)

N° du produit ABIN2776144

Détail du produit anti-KCNN2 anticorps

Antigène: KCNN2 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNN2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL NDQANTLVDL AKTQNIMYDM

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against KCNN2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 579 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KCNN2 (ABIN2776144)

Chakroborty, Kim, Schneider, Jacobson, Molgó, Stutzmann: "Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 24, pp. 8341-53, (2012) (PubMed).

Détails sur KCNN2

Antigène: KCNN2 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2))

Autre désignation: KCNN2 (KCNN2 Produits)

Synonymes: anticorps KCNN2, anticorps SK2, anticorps KCa2.2, anticorps SKCA2, anticorps SKCa 2, anticorps hSK2, anticorps fri, anticorps potassium calcium-activated channel subfamily N member 2, anticorps potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, anticorps KCNN2, anticorps Kcnn2

Sujet: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN2 is a member of the KCNN family of potassium channel genes.
Alias Symbols: SK2, hSK2, SKCA2, KCa2.2
Protein Interaction Partner: SRPK2, SRPK1, UBC, ACTN2, KCNN2, CALM1,
Protein Size: 579

Poids moléculaire: 64 kDa

ID gène: 3781

NCBI Accession: NM_021614, NP_067627

UniProt: Q9H2S1