LKB1 anticorps (N-Term)

N° du produit ABIN2776968

Cet anticorps Lapin Polyclonal détecte spécifiquement LKB1 dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien, Cheval et Cobaye.

Aperçu rapide pour LKB1 anticorps (N-Term) (ABIN2776968)

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LKB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-LKB1 anticorps

Épitope: N-Term

Séquence: TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHKNV IQLVDVLYNE

Homologie: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against STK11. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human STK11

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 433 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur LKB1

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Autre désignation: STK11

Sujet: STK11is a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in its gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms.This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Alias Symbols: LKB1, PJS, hLKB1
Protein Interaction Partner: SPDEF, SIRT1, PRKAA1, ETV4, CDC37, HSP90AA1, TP63, Eif2b1, Ap2m1, SNRK, APP, TNIP2, SIK1, STRADA, STUB1, UBE2D2, MARK2, GSK3B, STRADB, CAB39, KIF23, USP11, SMARCC1, SMARCA4, LIMS1, HSPA1A, FKBP5, RPAP3, MARK4, UBC, CAB39L, WDR48, RPS6KB1, MOB4, MARK1, RPS
Protein Size: 433

Poids moléculaire: 48 kDa

ID gène: 6794

NCBI Accession: NM_000455, NP_000446

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg