LKB1 anticorps (AA 19-48)

N° du produit ABIN3032541

Détail du produit anti-LKB1 anticorps

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Épitope: AA 19-48

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LKB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat, Chicken

Purification: Purified

Immunogène: A portion of amino acids 19-48 from the human protein was used as the immunogen for this LKB1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the LKB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the LKB1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur LKB1

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Autre désignation: LKB1 (STK11 Produits)

Synonymes: anticorps pjs, anticorps LKB1, anticorps XEEK1, anticorps Stk11, anticorps PJS, anticorps hLKB1, anticorps AA408040, anticorps Lkb1, anticorps Par-4, anticorps R75140, anticorps mLKB1, anticorps wu:fj61a05, anticorps zgc:110180, anticorps xeek1, anticorps serine/threonine kinase 11, anticorps polarization-related protein LKB1, anticorps serine/threonine kinase 11 L homeolog, anticorps STK11, anticorps stk11, anticorps LOC662493, anticorps Stk11, anticorps stk11.L

Sujet: LKB1 is a tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. [UniProt]

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg