CYP3A7 anticorps (Middle Region)

N° du produit ABIN2776998

Détail du produit anti-CYP3A7 anticorps

Antigène: CYP3A7 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 (CYP3A7))

Épitope: Middle Region

Reactivité: Humain, Rat, Boeuf (Vache), Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP3A7 est non-conjugé

Application: Western Blotting (WB)

Séquence: KSVKQIKEGR LKETQKHRVD FLQLMIDSQN SKDSETHKAL SDLELMAQSI

Homologie: Cow: 77%, Dog: 75%, Guinea Pig: 83%, Human: 100%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against CYP3A7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CYP3A7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 503 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CYP3A7 (ABIN2776998)

Van Peer, Verbueken, Saad, Casteleyn, Van Ginneken, Van Cruchten: "Ontogeny of CYP3A and P-glycoprotein in the liver and the small intestine of the Göttingen minipig: an immunohistochemical evaluation." dans: Basic & clinical pharmacology & toxicology, Vol. 114, Issue 5, pp. 387-94, (2014) (PubMed).

Détails sur CYP3A7

Antigène: CYP3A7 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 (CYP3A7))

Autre désignation: CYP3A7 (CYP3A7 Produits)

Synonymes: anticorps CP37, anticorps CYPIIIA7, anticorps P450-HFLA, anticorps cytochrome P450, family 3, subfamily A, polypeptide 7, anticorps cytochrome P450 family 3 subfamily A member 7, anticorps CYP3A7

Sujet: CYP3A7 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1.This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.
Alias Symbols: CP37, P450-HFLA, CYPIIIA7
Protein Size: 503

Poids moléculaire: 57 kDa

ID gène: 1551

NCBI Accession: NM_000765, NP_000756

UniProt: P24462

Pathways: Steroid Hormone Biosynthesis