SOCS1 anticorps (N-Term)

N° du produit ABIN2777164

Cet anticorps Lapin Polyclonal détecte spécifiquement SOCS1 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Porc, Lapin, Cheval, Chien et Cobaye.

Aperçu rapide pour SOCS1 anticorps (N-Term) (ABIN2777164)

Antigène: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Lapin, Cheval, Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SOCS1 anticorps

Épitope: N-Term

Fonction: SOCS1 Antibody - N-terminal region

Séquence: RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 93%, Horse: 90%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SOCS1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8113095

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur SOCS1

Antigène: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Autre désignation: SOCS1

Sujet:

Background Information: SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Gene Name: Suppressor of cytokine signaling 1

Alternative Symbols: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, TIP-3, SOCS-1

Protein Name: Suppressor of cytokine signaling 1

Poids moléculaire: 23kDa

ID gène: 8651

NCBI Accession: NP_003736

UniProt: O15524

Pathways: Signalistation JAK/STAT, Interferon-gamma Pathway, Signalisation TLR, Response to Growth Hormone Stimulus