Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2.
Alias Symbols: MGC13090, MGC20149, hMAF
Protein Interaction Partner: NFE2L2, PARP1, MAFG, DDIT3, BACH1, ATF3, BACH2, BATF3, MAFF, NFE2L3, NFIL3, NFE2L1, PIDD1, UBC, SNRPN, HSP90AA1, HIF1A, CYP2E1, SUMO1, SUMO2, SUMO3, PPP1CA, GTF2A1L, MED31, RBM48, CHD3, NFE2, PAX6, CREBBP, VIM, MAF, PRRX1, HOXD12,
Protein Size: 162