Kallikrein 6 anticorps (N-Term)

N° du produit ABIN2778179

Cet anticorps anti-Kallikrein 6 Polyclonal Lapin (ABIN2778179) détecte spécifiquement Kallikrein 6 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Chien et Cheval.

Aperçu rapide pour Kallikrein 6 anticorps (N-Term) (ABIN2778179)

Antigène: Kallikrein 6 (KLK6)

Reactivité: Humain, Chien, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Kallikrein 6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Kallikrein 6 anticorps

Épitope: N-Term

Fonction: KLK6 Antibody - N-terminal region

Séquence: KHNLRQRESS QEQSSVVRAV IHPDYDAASH DQDIMLLRLA RPAKLSELIQ

Homologie: Dog: 92%, Horse: 92%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against KLK6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human KLK6

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33888-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Kallikrein 6

Antigène: Kallikrein 6 (KLK6)

Autre désignation: KLK6

Sujet:

Background Information: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene that encodes KLK6 protein is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK6 is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease.Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.

Gene Name: Kallikrein-related peptidase 6

Alternative Symbols: hK6, Bssp, Klk7, SP59, PRSS9, PRSS18

Protein Name: Kallikrein-6

Poids moléculaire: 25kDa

ID gène: 5653

NCBI Accession: NP_001012982

UniProt: Q92876

Pathways: Système du Complément, Regulation of G-Protein Coupled Receptor Protein Signaling