DAZAP1 anticorps (Middle Region)

N° du produit ABIN2779144

Détail du produit anti-DAZAP1 anticorps

Antigène: DAZAP1 (DAZ Associated Protein 1 (DAZAP1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Cobaye, Cheval, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DAZAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: GKKVEVKRAE PRDSKSQAPG QPGASQWGSR VVPNAANGWA GQPPPTWQQG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against DAZAP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human DAZAP1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 401 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DAZAP1

Antigène: DAZAP1 (DAZ Associated Protein 1 (DAZAP1))

Autre désignation: DAZAP1 (DAZAP1 Produits)

Synonymes: anticorps MGC89358, anticorps DAZAP1, anticorps 2410042M16Rik, anticorps mPrrp, anticorps DAZ associated protein 1, anticorps DAZ associated protein 1 L homeolog, anticorps dazap1, anticorps DAZAP1, anticorps Dazap1, anticorps dazap1.L

Sujet: In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. DAZAP1 is a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.
Alias Symbols: MGC19907
Protein Interaction Partner: UBC, WWOX, RPA3, RPA2, RPA1, SUZ12, RNF2, EZH2, BMI1, rev, ITCH, RAD52, VCAM1, ITGA4, FN1, BRCA1, CAND1, COPS5, CUL1, CUL2, CUL3, CUL4B, CUL5, NEDD8, ELAVL1, SUMO2, DAZ1, DAZL,
Protein Size: 401

Poids moléculaire: 43 kDa

ID gène: 26528

NCBI Accession: NM_018959, NP_061832

UniProt: Q96EP5