TAF15 anticorps (N-Term)

N° du produit ABIN2779283

Détail du produit anti-TAF15 anticorps

Antigène: TAF15 (TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa (TAF15))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cobaye, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAF15 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: TDSSYGQNYS GYSSYGQSQS GYSQSYGGYE NQKQSSYSQQ PYNNQGQQQN

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Yeast: 77%

Attributs du produit: This is a rabbit polyclonal antibody against TAF15. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TAF15

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 592 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-TAF15 (ABIN2779283)

Schatz, Brändlein, Rückl, Hensel, Vollmers: "Diagnostic and therapeutic potential of a human antibody cloned from a cancer patient that binds to a tumor-specific variant of transcription factor TAF15." dans: Cancer research, Vol. 70, Issue 1, pp. 398-408, (2010) (PubMed).

Lee, Kim, Pelletier, Kim: "Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src." dans: FEBS letters, Vol. 564, Issue 1-2, pp. 188-98, (2004) (PubMed).

Détails sur TAF15

Antigène: TAF15 (TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa (TAF15))

Autre désignation: TAF15 (TAF15 Produits)

Synonymes: anticorps 2610111C21Rik, anticorps 68kDa, anticorps TAFII68, anticorps Taf2n, anticorps Npl3, anticorps RBP56, anticorps TAF2N, anticorps TATA-box binding protein associated factor 15, anticorps Taf15, anticorps TAF15

Sujet: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. Its gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.
Alias Symbols: Npl3, RBP56, TAF2N, TAFII68, hTAFII68
Protein Interaction Partner: RPA3, RPA2, RPA1, SUZ12, RNF2, EZH2, BMI1, EED, UBD, PRMT8, MED26, UBC, FUS, TPR, TPM2, DDB1, SCARB2, RNF168, TMED9, SAP30BP, NEDD8, CAND1, DCUN1D1, COPS5, COPS6, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, YWHAZ, SIRT7, HIST2H4A, HIST1H3A, HIST2H2AC, CACNA1A,
Protein Size: 592

Poids moléculaire: 61 kDa

ID gène: 8148

NCBI Accession: NM_139215, NP_631961