TYK2 anticorps (C-Term)

N° du produit ABIN2779322

L’anticorps Lapin Polyclonal anti-TYK2 a été validé pour WB. Il convient pour détecter TYK2 dans des échantillons de Humain, Souris, Rat, Chien, Cheval, Cobaye et Boeuf (Vache).

Aperçu rapide pour TYK2 anticorps (C-Term) (ABIN2779322)

Antigène: TYK2 (Tyrosine Kinase 2 (TYK2))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Cobaye, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYK2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TYK2 anticorps

Épitope: C-Term

Séquence: HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP

Homologie: Cow: 91%, Dog: 100%, Guinea Pig: 91%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against TYK2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human TYK2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1187 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TYK2

Antigène: TYK2 (Tyrosine Kinase 2 (TYK2))

Autre désignation: TYK2

Sujet: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Alias Symbols: JTK1
Protein Interaction Partner: KHDRBS2, KRT40, TRAF4, HNRNPK, FHL3, COPS5, JAK3, UBC, HSP90AA1, TYK2, PTAFR, EIF2AK2, LNX1, KLF10, SOCS1, TK1, DNM2, IFNAR1, JAKMIP1, XRCC5, STAM2, PRMT5, IFNAR2, CRKL, GHR, IRS2, IL6ST, STAT2, STAT1, IL13RA1, GNB2L1, PTPN1, PTPN6, PDGFRB, PLAUR, PIK3R1,
Protein Size: 1187

Poids moléculaire: 134 kDa

ID gène: 7297

NCBI Accession: NM_003331, NP_003322

UniProt: P29597

Pathways: Signalistation JAK/STAT, Hepatitis C