DNMT1 anticorps (N-Term)

N° du produit ABIN2779926

L’anticorps Lapin Polyclonal anti-DNMT1 a été validé pour WB. Il convient pour détecter DNMT1 dans des échantillons de Souris.

Aperçu rapide pour DNMT1 anticorps (N-Term) (ABIN2779926)

Antigène: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNMT1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DNMT1 anticorps

Épitope: N-Term

Séquence: SSVATRRTTR QTTITAHFTK GPTKRKPKEE SEEGNSAESA AEERDQDKKR

Homologie: Mouse: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Dnmt1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of mouse Dnmt1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Antigen size: 1619 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DNMT1

Antigène: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Autre désignation: Dnmt1

Sujet: Dnmt1 methylates CpG residues.Dnmt1 preferentially methylates hemimethylated DNA. Dnmt1 associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.Dnmt1 associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones.Dnmt1 mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, Dnmt1 is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Alias Symbols: Cxxc9, Dnmt, Dnmt1o, MTase, Met-1, Met1, MommeD2, MCMT, m.MmuI
Protein Interaction Partner: Uhrf1, Parp1, Eed, hist1h3g, DSK2, VPS9, Kat5, Ubc, Atm, NUB1, UBQLN1, SQSTM1, PSMD4, NBR1, RAD23B, Hesx1, Ezh2, Zbtb16, Cul3, Cdh1, Dmap1, Tcf3, hist1h4a, hist1h2bj, hist2h2ab, Dnmt1, Kcnq1ot1, Pla2g2a, Apc, Tox3, Rela, HDAC1,
Protein Size: 1619

Poids moléculaire: 183 kDa

ID gène: 13433

NCBI Accession: NM_010066, NP_034196

UniProt: P13864

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2