HBEGF anticorps (N-Term)

N° du produit ABIN2782149

Détail du produit anti-HBEGF anticorps

Antigène: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Chien, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HBEGF est non-conjugé

Application: Western Blotting (WB)

Séquence: FLAAVLSALV TGESLERLRR GLAAGTSNPD PPTVSTDQLL PLGGGRDRKV

Homologie: Cow: 100%, Dog: 86%, Guinea Pig: 79%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HBEGF. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human HBEGF

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur HBEGF

Antigène: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Autre désignation: HBEGF (HBEGF Produits)

Synonymes: anticorps hbegf, anticorps zgc:165443, anticorps HBEGF, anticorps zgc:175091, anticorps DTR, anticorps DTS, anticorps DTSF, anticorps HEGFL, anticorps Dtr, anticorps GFHB, anticorps Hb-egf, anticorps Hegfl, anticorps AW047313, anticorps Dts, anticorps HB-EGF, anticorps heparin-binding EGF-like growth factor b, anticorps heparin binding EGF like growth factor, anticorps Heparin-binding EGF-like growth factor, anticorps heparin-binding EGF-like growth factor a, anticorps heparin-binding EGF-like growth factor, anticorps hbegfb, anticorps HBEGF, anticorps hbegf, anticorps hbegfa, anticorps Hbegf

Sujet: HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
Alias Symbols: DTR, DTS, DTSF, HEGFL
Protein Interaction Partner: Bag1, BCL6, ZBTB16, CD82, NRD1, LTBP3, ERBB4, MMP7, CD9, FBLN1, EGFR, HBEGF, CD44,
Protein Size: 208

Poids moléculaire: 22 kDa

ID gène: 1839

NCBI Accession: NM_001945, NP_001936

UniProt: Q99075

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway