CTH anticorps (N-Term)

N° du produit ABIN2782463

Cité dans 3 publications. Cet anticorps anti-CTH Polyclonal Lapin (ABIN2782463) détecte spécifiquement CTH dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Cobaye, Cheval et Porc.

Aperçu rapide pour CTH anticorps (N-Term) (ABIN2782463)

Antigène: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Cobaye, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTH est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CTH anticorps

Épitope: N-Term

Fonction: CTH Antibody - N-terminal region

Séquence: VPPISLSTTF KQGAPGQHSG FEYSRSGNPT RNCLEKAVAA LDGAKYCLAF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 92%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CTH. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CTH

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46067-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CTH (ABIN2782463)

Perry, Kumai, Porteus, Tzaneva, Kwong: "An emerging role for gasotransmitters in the control of breathing and ionic regulation in fish." dans: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, Vol. 186, Issue 2, pp. 145-59, (2016) (PubMed).

Kumai, Porteus, Kwong, Perry: "Hydrogen sulfide inhibits Na+ uptake in larval zebrafish, Danio rerio." dans: Pflügers Archiv : European journal of physiology, Vol. 467, Issue 4, pp. 651-64, (2015) (PubMed).

Porteus, Abdallah, Pollack, Kumai, Kwong, Yew, Milsom, Perry: "The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio)." dans: The Journal of physiology, Vol. 592, Issue 14, pp. 3075-88, (2014) (PubMed).

Détails sur CTH

Antigène: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Autre désignation: CTH

Sujet:

Background Information: CTH is a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in its gene cause cystathioninuria.This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Gene Name: Cystathionase (cystathionine gamma-lyase)

Alternative Symbols: MGC9471

Protein Name: Cystathionine gamma-lyase

Poids moléculaire: 45 kDa

ID gène: 1491

NCBI Accession: NP_001893

UniProt: P32929

Pathways: ER-Nucleus Signaling, L'effet Warburg