PSMB9 anticorps (C-Term)

N° du produit ABIN2782473

Détail du produit anti-PSMB9 anticorps

Antigène: PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien, Porc, Lapin, Boeuf (Vache), Cheval, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMB9 est non-conjugé

Application: Western Blotting (WB)

Séquence: RRFTTDAIAL AMSRDGSSGG VIYLVTITAA GVDHRVILGN ELPKFYDE

Homologie: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PSMB9. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human PSMB9

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 219 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PSMB9

Antigène: PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))

Autre désignation: PSMB9 (PSMB9 Produits)

Synonymes: anticorps LMP2, anticorps ring12, anticorps MHC-linked, anticorps psmb9b, anticorps lmp2, anticorps lmp2b, anticorps psmb9, anticorps Lmp-2, anticorps Lmp2, anticorps PSMB6i, anticorps RING12, anticorps beta1i, anticorps psmb9-A, anticorps macropain, anticorps prosome, anticorps wu:fa66f04, anticorps wu:fj22d05, anticorps zgc:91842, anticorps psmb9a, anticorps proteasome subunit beta 9, anticorps LMP2, anticorps proteasome subunit beta type-9b, anticorps proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2), anticorps proteasome subunit beta 9 S homeolog, anticorps proteasome subunit beta 9a, anticorps proteasome (prosome, macropain) subunit, beta type, 9a, anticorps psmb9, anticorps PSMB9, anticorps psmb9-b, anticorps Psmb9, anticorps psmb9.S, anticorps psmb9a

Sujet: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. PSMB9 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This subunit is involved in antigen processing to generate class I binding peptides. Expression of PSMB9 is induced by gamma interferon and it replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding different isoforms have been identified, both isoforms are processed to yield the same mature subunit.
Alias Symbols: LMP2, MGC70470, RING12, PSMB6i, beta1i
Protein Interaction Partner: NCOA3, TCEB3, SRC, POLR2L, POLR2K, POLR2J, POLR2I, POLR2H, POLR2G, POLR2F, POLR2E, POLR2D, POLR2C, POLR2B, ESR1, NCOA2, UBC, HCVgp1, PSMA2, PSMB5, PSME2, PSME1, PSMB6, PSMA3, POMP, PSMB8, PSMB7, PSMA7, PSMA1, PSMB9, PSMC5, PSMA4, POLR2A, NCOA1, PSMB10,
Protein Size: 219

Poids moléculaire: 21 kDa

ID gène: 5698

NCBI Accession: NM_002800, NP_002791

UniProt: P28065

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA