Reticulon 4 anticorps (Middle Region)

N° du produit ABIN2782749

Il existe 1 publication pour ce produit. L’anticorps anti-Reticulon 4 Polyclonal Lapin est utilisé pour la détection de Reticulon 4 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Mouton, Cheval, Cobaye, Porc et Poisson zèbre (Danio rerio). Il a été validé pour WB.

Aperçu rapide pour Reticulon 4 anticorps (Middle Region) (ABIN2782749)

Antigène: Reticulon 4 (RTN4)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Mouton, Cheval, Cobaye, Porc, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Reticulon 4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Reticulon 4 anticorps

Épitope: Middle Region

Fonction: RTN4 Antibody - middle region

Séquence: FRIYKGVIQA IQKSDEGHPF RAYLESEVAI SEELVQKYSN SALGHVNCTI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against RTN4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RTN4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46812-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Reticulon 4 (ABIN2782749)

Beetz, Koch, Khundadze, Zimmer, Nietzsche, Hertel, Huebner, Mumtaz, Schweizer, Dirren, Karle, Irintchev, Alvarez, Redies, Westermann, Kurth, Deufel, Kessels, Qualmann, Hübner: "A spastic paraplegia mouse model reveals REEP1-dependent ER shaping." dans: The Journal of clinical investigation, Vol. 123, Issue 10, pp. 4273-82, (2013) (PubMed).

Détails sur Reticulon 4

Antigène: Reticulon 4 (RTN4)

Autre désignation: RTN4

Sujet:

Background Information: RTN4 belongs to the family of reticulons. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. RTN4 is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.

Gene Name: Reticulon 4

Alternative Symbols: ASY, NSP, NOGO, RTN-X, NSP-CL, RTN4-A, RTN4-C, RTN4-B1, RTN4-B2, NI220/250, Nbla00271, Nbla10545

Protein Name: Reticulon-4

Poids moléculaire: 42kDa

ID gène: 57142

NCBI Accession: NP_997403

UniProt: Q9NQC3

Pathways: Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome